PGxCheck...What is our DNA saying?

 

 

 

We need to consider how genetic information

can help us with respect to healthcare. We are able to perform genetic testing more readily,

but how are we using the results? Join in the discussion!

Welcome

Personalized medicine and pharmacogenomics (the influence of genetics on drugs) is here. It is in its infancy and we all will watch it grow. From healthcare professionals to the general public, pharmacogenomics and the broader area of personalized medicine will present a learning curve.


This blog is made possible through an individual making their genetic information available. 

As we learn what this individual's genetics are telling us...and what it is not telling us, we will discuss it. I am sure there will be many questions. We will have individuals from pharmacy, genetics, ethics, law, and other disciplines adding their expertise and thoughts to the discussion. I sincerely hope you will contemplate the information, formulate your thoughts, and participate in the discussion!

A quick look at DNA, Amino Acids, and Proteins

Before we go on with more disease risk information, I wanted to point out a brief review that you need to go look at and read. This takes the previous post information about DNA just a bit "farther". For most of you, this will be a review, but I thought it best to have you look at a short notation on DNA, amino acids, and proteins. The following link is to a website set up for the general public by the Ohio Northern University Raabe College of Pharmacy and the University of Florida College of Pharmacy student chapters of the Personalized Medicine Coalition (PMC). The site is called "Drugs and Genes". For now, go to (click on) www.drugsandgenes.com and click on the "DNA" tab next to "HOME" in the middle of the page. Read the information about DNA, amino acids, and proteins. We will refer to this site again in future posts. That''s it for this post!

2 comments | Add a New Comment
1. Diana Ivankovic | September 15, 2013 at 09:57 PM EDT

I have enjoyed the review of the \central dogma\- from DNA to RNA to proteins. The link has been very helpful in individuals, who unlike you, are at a high risk of developing coronary heart disease. Based on the genetic make-up of an individual, the perfect drug can be prescribed, without having to give a drug that is not helping at all and causing the patient to relapse (see the example in your link of Plavix given to a patient who is not responding to it). About nine years ago they came up with a test in cancer patients which, based on genetic tests from the biopsied tissue, could determine the exact chemotherapeutic drug to be given to the individual. I was diagnosed with breast cancer a few months before, so I had to take a \cocktail of chemo drugs\, just in case. Side effects and lives lost in vain will all be avoided with personalized medicine!

2. Julia Christian | September 20, 2013 at 01:58 PM EDT

In the article, Pharmacogenomics and the Brave New World of Personalized Medicine, (DE PALMA, 2006), the author presents that the institution of a more personalized medications through genetic makers would reduce potential drug toxicity in patients and increase effectiveness. The author also recognizes that this change in the medication process will have a marked change on how drugs are sold and made available. Drug companies would no longer make a standard, large-quantity product. They would be required to make several variations of drugs for the same disease in smaller amounts in order to meet the needs of the diverse genotypes.

This BSN student compares concludes that the implementation of more specialized care is very desirable for the patient. There will be a smaller likelihood of adverse effects if the drug is tailored to the needs of the patient. This, in many cases, would provide quicker results and less stress on the individual. A negative to more specialized medications would be the raise in cost of treatment for the patient. Drug companies would require more income to produce smaller amounts of more specialized medication options.

Resources:

DE PALMA (2006). Pharmacogenomics and the Brave New World of Personalized Medicine. PharmaManufacturing.com.

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